透過皮膚傳輸兒茶素的技術
We used amphiphilic PEG-PCL modified cellulose to enhance the permeation flux of green tea extract (GTE) in the skin. In the pharmacokinetic data, the absorption of GTE in rat plasma via transdermal route was significantly enhanced, compared with that of oral administration. This study was published many years ago (Journal of Membrane Science 371 (2011) 134–140) and it was cited in another paper (JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 160, 318-329,JUL 2016). Herein, we compared the data in these two papers and discuss their common findings.
本實驗室於2011年前發表一篇經皮吸收綠茶萃取物的文章，透過親疏水調控的纖維素薄膜，綠茶萃取物在大鼠血漿中的濃度遠高於口服兒茶素，顯見本實驗室開發的薄膜具有皮膚滲透調控功能。2016年有篇文章引用我們的文章，以下說明這兩篇文章的發現：
Our paper indicated AUC (area under the serum concentration of GTE in rat plasma) of PEG-PCL-HEC membrane can be 10 times higher than that of orally-administrated GTE. 我們的文章報導以薄膜傳輸的綠茶萃取物在動物血漿濃度是口服劑型的10倍以上。
2. citing paper developed nano-sized emulsion of GTE and found similar pharmcokinetic profile with our study.
引用我們研究的文章(2016)報導的藥物動力學數據與我們文章(2011)有相同結果：
皮膚吸收優於口服。 顯見具有親膚的綠茶萃取物劑型比起口服劑型更具人體吸收功效。
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